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In nature, gadolinium mostly exists in its oxidized forms. Gadolinium is mainly present in China, US, Brazil, Sri Lanka, India and Australia. It is isolated from its minerals through ion exchange and solvent extraction process. It can be produced through the reduction of anhydrous gadolinium fluoride with calcium metal [2]. Physical Characteristics

















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Following the injection of the contrast agent, the IV line will be flushed with some saline. Gadolinium-based MRI contrast agent is administered intravenously in approximately, 0.2 mL/kg (0.1 mmoles/ kg) at a rate of 10 mL per 15 seconds. Gadolinium-based MRI contrast agents come from the manufacturer in following packages: 1.













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Mechanism of Action. Gadolinium (Gd 3+), in its raw form is a paramagnetic ion composed of seven unpaired electrons 1 resulting in a highly magnetic effect. Administration of Gd 3+ falters the rotation frequency of water molecules, shortening both T1 and T2 relaxation times of tissues in which it accumulates, thus allowing …



5.3 Gadolinium Retention Gadolinium is retained for months or years in several organs. The highest concentrations (nanomoles per gram of tissue) have been identified in the bone, followed by other organs (for example, brain, skin, kidney, liver, and spleen). The duration of retention also varies by tissue and is longest in bone.
